The Italian tactician was disappointed after his City side won their final Champions League Group A game 2-0 against Bayern Munich at the Etihad Stadium on Wednesday only to go out of the competition due to Napoli's 2-0 win at Villarreal.
It means Mancini must try and raise his players for a tilt at winning the Europa League in the second half of the campaign, while maintaining their push for a first ever Premier League crown.
However, he does not feel that will impact on their title bid, especially with neighbours and closest rivals Manchester United also facing Europa League football after their shock Champions League exit on Wednesday.
"I think that for the Premier League it changes nothing because both teams are in the Europa League," said Mancini.
"The difference is that the Europa League is harder because we play Thursday and we won't have a lot of time to recover for the games but this will be the only difference," he added.
On the Europa League, Mancini added: "I think that for Manchester City it's an important trophy because we need to win more trophies if it's possible."
"At the moment I can understand that the Europa League is not as important as the Champions League but for us it will be important and if we can go to the final it would be good for Manchester City."