City's defence of their Premier League crown has gone awry recently following two consecutive draws, leaving them nine points behind rivals Manchester United in the battle for top spot.
It is no coincidence that the Citizens have struggled since Toure left for the Africa Cup of Nations but following the Ivory Coast's surprise exit from the tournament, the powerful central midfielder is back in the first-team picture.
Toure, along with brother Kolo, are both back in Manchester and should be available for Saturday's trip to St Mary's.
Kompany's participation is a little more doubtful as the City skipper continues to struggle with the calf injury he suffered in the 1-0 win over Stoke in the FA Cup fourth round last month.
The Belgian central defender wasn't expected to be available again until City took on Chelsea on February 24 but assistant manager David Platt has revealed he has an outside chance of facing Southampton.
"The injury problems aren't as bad now," Platt told the Manchester Evening News. "There is nothing definite to say Vinny will make it for Southampton, but he has a chance."
Should Kompany prove his fitness before this weekend's game then manager Roberto Mancini will have a near fully-fit squad to choose from, with Micah Richards the only other injury absentee.