The England duo both missed the 4-2 international friendly defeat in Sweden this week as they continued their return from respective hamstring and back problems.
However, they are set to be in City boss Roberto Mancini's plans at the Etihad Stadium this weekend.
Left-back Gael Clichy could also be fit after missing France's midweek international against Italy because of back trouble and forward Samir Nasri has recovered from illness.
Striker Mario Balotelli will hope to play after being dropped last week but midfielder Jack Rodwell and right-back Micah Richards are not ready to return from hamstring and knee injuries respectively.
Sergio Aguero has spoken out to claim City have yet to display their best form this season, while he feels close to his full match sharpness after early-season injury problems.
He told the club's website: "It's true that we don't have the same flair in the games as we had last season and we've scored less goals for sure.
"But the Premier League table says something different. We are very hard to beat, we are second in the table and defending well, so we can't be doing that badly, can we?
"We have been hindered by a string of bad injuries to important players - David, Pablo, Javi Garcia, Micah, Joleon, Maicon, Barry, Milner, Samir, myself...it's not simple when they all happen simultaneously and I think I'm correct in saying we had very few injuries last season.
"If we have been succeeding even in spite of these difficulties, then it makes me believe that the best is still to come and we'll be able to repeat our form of last year."