City boss Manuel Pellegrini had hoped that central defender Kompany would be fit from his latest injury, which has sidelined him since last month's 3-1 win against Everton, in time to face Spurs at the Etihad Stadium.
However, a slight setback has meant he will not be ready, although Pellegrini is hoping to have the Belgium international back in training next week.
Spanish playmaker Silva is currently sidelined because of a calf injury he picked up during the 5-2 Champions League win against CSKA Moscow earlier this month, while striker Jovetic is also absent with a calf injury.
City are set to be boosted by the fitness of defender Matija Nastasic and midfielder Fernandinho, while Pellegrini has hinted that Joe Hart might feature in goal after he played "very well" for England against Germany on Tuesday.
The Chilean tactician confirmed at his Friday press conference that he will decide if Hart will get the nod ahead of Costel Pantilimon before the game.
Pellegrini is calling for his side to stretch their 100 percent home record and secure three points to get back into the top-four reckoning having slipped down to eighth.
He said: "It is a tough match. I think they are a very good team. They have good players and play very good football.
"If we want to continue winning at home we need to play a very good game."