Toure had to settle for a place on the bench in the victory over Chelsea in the club's last outing.
Sunderland go into the match on the back of a impressive 4-0 victory against Bolton but boss Roberto Mancini is looking for nothing less than a win.
He said: "I think beating Chelsea will help our confidence as we played very well.
"It is important we win this game if we want to continue our improvement. In the last three of four games we have performed very well.
"It will be a difficult game against Sunderland. It is important we forget about Chelsea as this will be a different test. We need to show good concentration and play 100%."
However, Mancini is without Emmanuel Adebayor through suspension while Martin Petrov is injured as City look to push for a top four finish.