The City boss has admitted that £27million striker Edin Dzeko will be his only acquisition during this January transfer window, but he is now trimming down his over-sized squad of players who are desperate to move for first-team football.
Full-back Wayne Bridge sealed a loan move to West Ham earlier in the week and Mancini has now revealed that Paraguayan hitman Santa Cruz will move to his former club Blackburn in the coming days as he looks like snubbing former City boss Mark Hughes' advances from Fulham.
"Roque will probably go to Blackburn," said Mancini.
"Every player wants to play. I understand that. But it is difficult for me.
"If an opportunity for either of them to play came up, then it would be better for them and I hope for Roque that in one or two days, he will have that."
Wright-Phillips has 'two or three options', according to Mancini with Fulham, West Ham and possibly Liverpool vying to take the England international winger in the window.
However Emmanuel Adebayor could be made to wait for a move out of Eastlands as Mancini wants to see how severe Mario Balotelli's knee injury is before allowing another striker to depart.
"A lot of teams want Emmanuel but at the moment we have to wait for Mario Balotelli," added Mancini.
"Maybe Manu will leave but we have another 20 days, so we have time to make a decision.
"If we lose three or four, we might end up in a situation where we don't have enough players for the remainder of the season."