The 20-year-old Italian international striker has had a mixed time since joining City from Inter Milan in a deal worth over £20million last summer. Balotelli has scored some impressive goals for the club, but two red cards, including one in the recent Europa League exit at the hands of Dynamo Kiev, has resulted in the young forward being publicly chastised by Mancini.
In addition to his disciplinary problems, Balotelli has also been at the centre of some off-field antics which has left Mancini issuing a stern warning to the player.
"He is 20 and at that age people do c**p things," he said.
"But maybe now the time has come for him to help himself and to understand the mistakes he is making.
"Otherwise he risks throwing away his abilities which are immense. He has scored some beautiful goals this season.
"He should think only about expressing his talents on the pitch and leaving to one side the other matters which have nothing to do with football.
"If he does not, then everybody in England will begin to make him a target - starting off with the referees.
"I understand him and everybody has infinite patience with Mario. Everyone at Manchester City has always helped him and wish him the best."