Red Devils boss David Moyes has found the going tough since taking over from Sir Alex Ferguson in the summer, and for the first time in years United have stuttered through the first few months of the campaign.
Despite their poor start the former Everton boss is hopeful he will be able to help them retain the title.
United currently sit eight points behind Arsenal in the race for the Premier League crown, but Toure believes that Liverpool are now a greater threat to City's title ambitions than their local rivals.
He said in The Sun: "United will find it hard to defend the title since they have a new manager and are really struggling.
"Liverpool are a big threat at the moment because they have a strong squad and their strikers - Luis Suarez and Daniel Sturridge - are scoring goals at will."
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