The 31-year-old Bulgarian hitman, who has scored 56 goals in 147 United appearances since being signed from Tottenham in summer 2008 for £30.75million, has struggled for first-team action under Sir Alex Ferguson over the past 12 months.
Berbatov was United's top scorer last season, but that did not stop him from falling down the pecking order following Javier Hernandez's rise to prominence in the second half of the campaign.
It was thought that Berbatov would leave Old Trafford in the summer months when several clubs, including Bayern Munich, expressed an interest in him.
However, despite his decision to stay put, Berbatov remained behind Wayne Rooney, Hernandez and Danny Welbeck in Ferguson's pecking order.
The Scot confirmed last week that United would listen to offers for Berbatov in the summer as he can not guarantee him the first team football he wants.
And, Berbatov's agent Emil Danchev has now told the Bulgarian media that his client is almost certain to be leaving United for pastures new at the end of the season.
He said: "I had three meetings with (United manager) Alex Ferguson. We should accept that he'll try to build a team for the next three or four years and Berbatov will not be part of this team.
"Ferguson wants to change the playing style, to implement more speed. I was pleased with United's position as they said they'll not oppose Berbatov's move in the summer."
Danchev added: "Dimitar will most probably leave England but he doesn't want to move to the U.S., Japan, United Arab Emirates or championships like these."