The Red Devils travel to east London looking to keep their record 19th title bid on track with three points against a Hammers side that needs points to stay out of the relegation places.
And, United chief Sir Alex Ferguson will be hoping South Korean midfielder, Park, and Brazilian star, Anderson, can ease his injury and suspension problems by making the squad following recent hamstring and knee injuries respectively.
In defence United were boosted by centre-back Nemanja Vidic proving his fitness in Serbia's Euro 2012 qualifying draw against Estonia in midweek. And, while Rio Ferdinand is back in training, the game against his former club will come too soon so Chris Smalling could feature alongside Vidic as Jonny Evans is suspended following his red card against Bolton last time out.
Darren Fletcher, John O'Shea and Rafael are among others still on the sidelines due to injury, while Paul Scholes is also suspended.