The Serbian centre-half has not featured since September after being forced to undergo a knee operation.
The initial prognosis suggested Vidic would be out of action until the new year but the defender has made a quicker-than-expected recovery and is available to face Sunderland at Old Trafford on Saturday.
Boss Sir Alex Ferguson has confirmed Vidic is now available, and his return comes as a timely boost for the league leaders as Jonny Evans picked up a knock in the win over Manchester City last time out.
"It would have been crazy to play him against City but against Sunderland...definitely," said Ferguson.
"It's a big bonus to have him back. He is a real competitor with that uncompromising way of his. He likes defending - that's what it is.
"In the last 18 months he has only had 10 games or something. It is not many games that he has played. Now he has no pain in the knee, and it's a different knee to the one he did his cruciate on."