Luke Shaw, Ashley Young and Marcos Rojo remain unavailable to the Portuguese tactician as they continue to recover from long-term injuries sustained last season.
Eric Bailly and Phil Jones missed Tuesday's UEFA Super Cup defeat to Real Madrid through suspension, but their continental bans do not impact domestic matches.
Romelu Lukaku is set to start up front with fellow new signing Nemanja Matic included in a three-man midfield with Ander Herrera and Paul Pogba.
Victor Lindelof will probably have to settle for a place on the bench after one or two uncertain performances in pre-season.
Provisional squad: De Gea, Romero, J Pereira, Valencia, Darmian, Blind, Jones, Bailly, Smalling, Lindelof, Tuanzebe, Matic, Carrick, Fellaini, Herrera, McTominay, Pogba, Lingard, Mkhitaryan, Mata, A Pereira, Martial, Rashford, Lukaku