Manchester United insiders claim there are already concerns the 19-year-old might be in need of a rest, going in to a critical run of fixtures which will first see Jose Mourinho's team travel to Anfield, before also taking on Chelsea and Tottenham Hotspur over the next month.
Rashford has been heavily involved for the Red Devils and England in the opening months of the new campaign, with Mourinho's staff now wary of making too many demands and risking a potential muscle injury.
The United starlet has formed a potent understanding with new signing Romelu Lukaku, sharing 20 goals between them so far in all competitions.
Mourinho has publicly conceded he is struggling to hand his forwards a rest because of the ongoing injury absence to Zlatan Ibrahimovic, with the Swede now in the final stages of his recovery from damaged knee ligaments.
The Manchester giants, however, have particular reservations over Rashford playing too many minutes, due to him still growing, physically, allied to the fact his game is more heavily-reliant on pace than Lukaku.
Mourinho's conditioning staff have the data to back up their thinking and it may just be a question of when the England starlet will now be taken out of the firing line, to keep him fully primed and fit, going in to the busy winter schedule.