Pogba picked up a hamstring problem in Thursday's 1-0 Europa League win over FC Rostov at Old Trafford and the midfielder is now set to miss the next three weeks.
United will also be without the suspended duo of Zlatan Ibrahimovic and Ander Herrera, with manager Jose Mourinho facing some tough selection decisions.
Defender Daley Blind is also a doubt for the weekend after sustaining a head injury against Rostov while captain Wayne Rooney's availability is uncertain after he picked up a knock in training.
Anthony Martial, Luke Shaw and Bastian Schweinsteiger will be all be hopeful of being selected after training away from the main group ahead of the previous game.
Provisional squad: De Gea, Romero, Valencia, Jones, Rojo, Smalling, Bailly, Blind, Darmian, Shaw, Young, Carrick, Fellaini, Schweinsteiger, Mata, Lingard, Mkhitaryan, Rooney, Martial, Rashford.