France international Pogba was rather underwhelming on his return to Old Trafford last season and many were questioning the £90million the club spent on signing him from Italian champions Juventus.
However, the 24-year-old has started the current campaign in much better fashion, scoring in the 4-0 victories against West Ham United and Swansea City, and he has been an integral part of the first team.
The Lagny-sur-Marne-born star was handed the captaincy on Tuesday for the Champions League clash against Basel but he only lasted 19 minutes of the 3-0 victory after pulling up injured when challenging for the ball.
Mourinho has now confirmed Pogba will be missing for Sunday's home Premier League clash against Everton but the Portuguese tactician is confident there is enough strength in his squad to cope.
"We have players and we have players waiting for an opportunity," he said. "Because we have started the season really well and with one match per week, (with) no need of resting, (to make) changes, we were basically going with the same players.
"But there are good players more than ready to play, so, honestly, we miss Pogba, we need Pogba, but we have good players. Herrera, Fellaini, Carrick, they are waiting - they are waiting for a real chance to start matches and to play matches from the beginning, and they are ready."
Ander Herrera, Michael Carrick and Marouane Fellaini will all be vying for a starting spot against the Toffees and the latter, who is a Belgium international who used to play for the Merseysiders, may have the edge after scoring against Basel.
Romelu Lukaku will line up against his former employers for the first time since making the summer switch to United and punters may decide to use their free bet on the striker firing his new team to all three points.