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Sam Hart and Alex Dobre could both make their Rochdale debuts against Southend.
AFC Wimbledon's new signing Joe Pigott is set to make his debut against Blackpool.
Luke Hendrie will be available again for Shrewsbury against Doncaster.
Northampton could hand a debut to defender Joe Bunney against MK Dons.
Scunthorpe will still be without goalkeeper Matt Gilks as they look to maintain their League One promotion push against Gillingham at Glanford Park.
Oxford are without Jack Payne when Bury visit in League One on Saturday.
Charlton could have midfielder Tarique Fosu-Henry back for Saturday's League One game at home to Walsall.
Fleetwood could have Ashley Eastham back for Saturday's League One game at home to Blackburn.
Plymouth host Wigan without defender Ryan Edwards, who has been diagnosed with testicular cancer.
George Cooper could make his Peterborough debut in Saturday's League One clash with Oldham.
Charlton climbed back into the League One play-off places after winning 1-0 at rock-bottom Bury.
Doncaster do not have many injury worries as they go into their Sky Bet League One game against Plymouth.
Portsmouth are likely to be without Ben Close and Nathan Thompson for Saturday's League One game at home to Scunthorpe.
Stuart McCall will welcome back players from all areas of the pitch as Bradford play Northampton at home.
Aidan Nesbitt is one of a handful of players MK Dons boss Robbie Neilson hopes will be fit again for the visit of rivals AFC Wimbledon.
Bury striker Ryan Lowe is suspended for the visit of Charlton.
Oldham boss Richie Wellens could have a series of new faces in his team when Rotherham head for the SportsDirect.com Stadium.
Wigan boss Paul Cook will have to make at least one change when Peterborough head for the DW Stadium.
Walsall boss Jon Whitney is hopeful Tyler Roberts and Florent Cuvelier will be available to face Oxford.
Blackburn could give a debut to on-loan Newcastle striker Adam Armstrong against Shrewsbury.
Defender Jason Pearce will be absent for Charlton's Sky Bet League One clash against Oldham.