Manchester City will be looking to bounce back from their first league loss of the season when they play host to Newcastle on Saturday.
Southampton and Tottenham need three points for very different reasons ahead of their meeting at St Mary's on Sunday.
West Ham and Bournemouth will both be aiming to pull further clear of the relegation zone when they meet at the London Stadium.
Everton are aiming to avoid a fifth straight defeat in all competitions when they play host to an improving West Brom on Saturday.
The wheels have threatened to come off Burnley's season of late and they will face a tough test against Manchester United on Saturday.
Paul Lambert will take charge of Stoke for the first time when they play host to Huddersfield at the bet365 Stadium on Saturday.
Mid-table Leicester and Watford will go head-to-head at the King Power Stadium on Saturday with both teams aiming for all three points.
Arsenal are expected to welcome back fit-again Mesut Ozil to their squad for Saturday's home clash with Crystal Palace.
Brighton will be aiming to halt their worrying slide towards the bottom three when they play host to Chelsea at The Amex on Saturday.
The one definitive answer we got last week is that Man City will not be going the whole Premier League season undefeated.
Spurs endured something of a mid-season blip back in November that threatened to derail their campaign, but they have definitely rediscovered their mojo now.
Manchester United will face managerless Stoke City at Old Trafford on Monday without the services of Zlatan Ibrahimovic.
Liverpool boss Jurgen Klopp will welcome back Mohamed Salah in time for Sunday's clash with Manchester City.
Southampton will look to win their first league game since November when they travel to Vicarage Road to face Watford.
Huddersfield boss David Wagner could give Terence Kongolo and Alex Pritchard their league debuts against West Ham this weekend.
Newcastle will be looking to extend their winning run to three matches then they take on Swansea City at St James' Park on Saturday.
West Brom will look to win their first league match since August when they welcome Brighton to The Hawthorns on Saturday afternoon.
Son Heung-min and Pedro Obiang each scored a stunner as Tottenham were held by West Ham to a 1-1 draw at Wembley.
Tottenham are expected to welcome Harry Kane back to the starting line up for Thursday's London derby with West Ham at Wembley.
Tottenham striker Harry Kane is expected to be back in the starting line-up in place of Fernando Llorente against West Ham on Thursday.
Arsenal will look to extend their unbeaten Premier League run to six games, when they face Chelsea at the Emirates on Wednesday night.