Southampton will look to win their first league game since November when they travel to Vicarage Road to face Watford.
Huddersfield boss David Wagner could give Terence Kongolo and Alex Pritchard their league debuts against West Ham this weekend.
Newcastle will be looking to extend their winning run to three matches then they take on Swansea City at St James' Park on Saturday.
West Brom will look to win their first league match since August when they welcome Brighton to The Hawthorns on Saturday afternoon.
Tottenham will look to extend their unbeaten run to six matches when they welcome Everton to Wembley on Saturday evening.
New loan signing Georges-Kevin NKoudou is set to make his debut as Burnley travel to Selhurst Park to take on Crystal Palace.
Chelsea will look to move into the top two for the time being on Saturday as they take on Leicester City at Stamford Bridge.
Bournemouth will look to move clear of the bottom three and put more pressure on Arsenal boss Arsene Wenger when they meet on Sunday.
Chelsea host Arsenal in the Carabao Cup semi-final first-leg on Wednesday, with the two sides meeting for the third time this season.
Man City will continue their hunt for the quadruple on Tuesday when they face Bristol City in the Carabao Cup semi-final first leg.
History will be made when Brighton play host to Crystal Palace in the third round of the FA Cup on Monday night.
A much-changed Tottenham team is expected to take to the field when they play host to AFC Wimbledon in the FA Cup third round.
League One high-flyers Shrewsbury will play host to improving West Ham in the FA Cup third round on Sunday.
Managerless Nottingham Forest face the daunting prospect of playing host to holders Arsenal in the FA Cup third round on Sunday.
Championship outfit Norwich will play host to Premier League giants Chelsea in the FA Cup third round on Saturday evening.
Top of the Championship takes on bottom of the Premier League as Wolves play host to Swansea in the FA Cup third round on Saturday.
Watford have already lost to Bristol City once this season and they will be looking to avoid a repeat when they meet in the FA Cup.
Newcastle enjoyed a solid festive period in the Premier League but they will be hoping to avoid an FA Cup shock against Luton.
Manchester City's domestic dominance so far this season will be put to the test when they take on Burnley in the FA Cup third round.
Fulham and Southampton will head into their FA Cup third round clash at Craven Cottage on Saturday in contrasting form.
West Brom will be hoping for a morale boosting victory when they travel to St James Park to take on Exeter in the FA Cup third round.