The Gunners will head into the final match of the season fifth in the standings, a point behind fourth-place Liverpool, while Manchester City, in third, are a further two points clear.
Arsene Wenger has guided Arsenal to at least a top four finish in each of his previous 20 seasons at the helm and momentum appears to be on the side of the Gunners, as they have won six of their last seven league games.
Wenger has also never lost a home match against Everton, with Arsenal's last defeat to the Toffees on home soil coming way back in January 1996.
Arsenal are sweating over the fitness of defender Laurent Koscielny, who missed the midweek victory over Sunderland with a calf problem, while he is also struggling with an ongoing Achilles complaint.
Midfielder Aaron Ramsey will also be hoping to feature despite limping out of the win against Sunderland with a leg problem, while Alex Oxlade-Chamberlain will definitely miss out due to a hamstring complaint.
Everton will head into the contest having already secured European football for next season and they are guaranteed to finish seventh in the standings regardless of the result at the Emirates Stadium.
The Toffees have enjoyed an impressive campaign to date, although they have only won one of their last four games, a 1-0 triumph against Watford last time out.
Boss Ronald Koeman has no new injury concerns heading into the match, although the contest could mark Romelu Lukaku and Ross Barkley's final appearances for the club, as both players have been liked with summer transfers.