The Clarets might have only won one of their last 10 matches in all competitions but are a force to be reckoned with at home, winning 10 of 16 matches, a run which includes victories over Liverpool, Everton and Leicester.
Another win at Turf Moor will all but guarantee Burnley's top flight status, moving them on to 39 points, but have only beaten United once in 22 attempts, with Robbie Blake scoring the winner in 2009.
Goalkeeper Tom Heaton was the star when the two sides met at Old Trafford earlier in the season, keeping a clean sheet as they held the Red Devils to a goalless draw.
Steven Defour could make his return after injuring his thigh against Stoke at the start of the month, while Johann Berg Gudmundsson is in contention after appearing for the Under-23s.
Burnley's injury list is minimal compared to Sunday's opponents, Zlatan Ibrahimovic and Marcos Rojo picking up knee injuries in the extra-time Europa League quarter-final second leg win over Anderlecht on Thursday.
The duo join Phil Jones, Chris Smalling and Juan Mata in the treatment room but United do at least have Wayne Rooney available after he returned to bench in midweek.
United are on a 22-match unbeaten run, boosting their chances of finishing in the top four having closed to within four points of fourth-placed Man City.