The Clarets have successfully preserved their place in the top-flight for next season thanks largely to their form on home soil, as they have collected 33 of their 40 points at Turf Moor.
Sean Dyche's men have emerged victorious in ten of their 18 home matches to date, although their form has dipped in recent weeks, as they have won just one of their last five home games.
Dyche will be sweating over the fitness of centre back Michael Keane, who has been linked with a move away from the club during the summer, and is currently struggling with a calf injury.
Fellow defender Ben Mee is also a doubt with the shin problem that has ruled him out of Burnley's last three matches.
West Ham have endured an underwhelming campaign, winning just two of their last 13 games and a top-half finish now appears to be out of reach.
Boss Slaven Bilic's future has come under scrutiny throughout the season, but a positive result at Turf Moor could go a long way to preserving his position at the London Stadium for next season.
The Hammers will certainly fancy their chances of returning from Lancashire with all three points, as they have won on their last two visits to Turf Moor, including a 3-1 success in October 2014.
Defender Winston Reid will miss the match however, as he has undergone surgery on a chronic knee injury that is expected to keep him out of action for ten weeks.
Youngster Declan Rice is expected to deputise in Reid's absence, while Mark Noble, Cheikhou Kouyate, Andy Carroll and Michail Antonio are just some of the other names on a lengthy injury list.