The Blues were emphatic 6-0 winners over Qarabag in the Champions League on Tuesday and they have 48 hours longer to prepare for the match than the Gunners, who beat Cologne 3-1 in the Europa League on Thursday.
Chelsea have won their last four games in all competitions and appear to have put their opening day defeat to Burnley well and truly behind them.
However, Antonio Conte's side do have an indifferent recent record against Arsenal, as they have only won one of the last four meetings between the two sides, a run that includes a 2-1 loss in last season's FA Cup final.
New signing Danny Drinkwater will definitely miss the match and he is likely to have to wait until October to make his debut for the club due to a calf complaint.
Conte is likely to make a number of changes after rotating his squad against Qarabag, which means Eden Hazard could make his first start of the season following an ankle injury.
Arsenal have won their last two matches in all competitions, but the pressure remains on Arsene Wenger's side following an indifferent start to the season.
The Gunners have lost their last two away games in the Premier League, following up a 1-0 defeat at Stoke with a high-profile 4-0 loss against Liverpool at Anfield.
The North Londoners have also lost on their last four visits to Stamford Bridge, including a 6-0 defeat at the venue in 2014.
Wenger made nine chances to his side against Cologne and he is expected to rotate his squad once again this weekend, with the likes of Petr Cech, Mesut Ozil, Laurent Koscielny, Aaron Ramsey and Alexandre Lacazette all hoping to return.