There have been quite a few changes in personnel at Stamford Bridge since they lifted the trophy in May and the Blues suffered a defeat in last weekend's Community Shield.
Antonio Conte has decided Diego Costa doesn't feature in his plans, while John Terry, Nemanja Matic, Asmir Begovic and Nathan Ake have left on a permanent basis and several others have gone out on loan.
Chelsea are also without injured duo Eden Hazard and Tiemoue Bakayoko while Victor Moses and Pedro are both suspended. But big-money signing Morata is being tipped to start against the Clarets, who have not won at Stamford Bridge since 1971, while defender Antonio Rudiger is also pushing for a starting berth.
The visitors have made five new additions this summer, with at least three of those expected to make their debuts on Saturday - Jack Cork, Charlie Taylor and Jon Walters. One big blow though for Sean Dyche came this week, with the departure of Andre Gray to Watford.
Burnley have never won an opening-day fixture in the Premier League era while, in contrast, Chelsea have gone 18 matches without defeat on the opening day of the season.