In-form Spurs have closed the gap on the Blues to four points at the top of the table, Antonio Conte’s men having lost two of their last four matches to allow their London rivals to move within touching distance.
Conte saw his men completely out played at Old Trafford last week as they went down to a 2-0 defeat.
The chance to book their place in the FA Cup and keep their double dream alive could therefore prove to be the perfect tonic for the Italian’s team.
Chelsea have a habit of turning up when it comes to matches at Wembley, winning seven of the last eight.
The Blues have concerns over the fitness of Gary Chill, the England centre-half having spent time in hospital this week due to an illness. Should Cahill not make it then Kurt Zouma is likely to replace him.
Goalkeeper Thiabaut Courtois is also a doubt after missing the defeat to United last week due to an ankle injury. Marcos Alonso is likely to return though after pulling out of the starting line-up at Old Trafford with an illness.
Chelsea will be out for revenge against Spurs having lost the last meeting between the two sides at White Hart Lane.
Pochettino’s men have been in fantastic form since that win in January and head to Wembley having won their last eight matches in all competitions.
Spurs are coming on strong at just the right time but face arguably their biggest test as they look to snap their Wembley hoodoo.
The north Londoners have already played four times at the national stadium this season having decided to stage their European games at the venue but have just one win to show for their efforts.
Its only two wins in nine matches at Wembley for Spurs but they will be full of confidence of taking out Chelsea given their recent performances.
Harry Kane came through the 4-0 win over Bournemouth unscathed so will start up front again.
Danny Rose will not feature having failed to recover from a knee injury in time, while Harry Winks, Erik Lamela and Michel Vorm are long term are long-term absentees.
January’s win for Spurs was just their second in the last 16 meetings between the London rivals.