The home side have got a poor record in games on the opening weekend, losing three of their last four opening-day matches in the Premier League - including a 0-1 home defeat to West Brom last season.
De Boer will also have to end a poor run of results against the Terriers, with Palace winning just one of their last 12 matches against Huddersfield - although they have not played each other since 2013.
At least two new signings are expected to feature for the Eagles on Saturday, with Jairo Riedewald and Ruben Loftus-Cheek pushing for starts - while Timothy Fosu-Mensah may have to settle for a place on the bench, having only joined from Manchester United this week.
Palace are hopeful that Yohan Cabaye will recover from an ankle problem in time to be involved, while James McArthur is also pushing for a start having recovered from injury.
The visitors, who are the favourites to be relegated this term, have made new fewer than nine additions this summer and a number of them are expected to start on Saturday - including the likes of Tom Ince, Steve Mounie and Kasey Palmer.
David Wagner expects to have new captain Tommy Smith available for selection after a recent foot injury, but Jonathan Hogg and Nahki Wells are both missing through injury.