The Terriers have made an impressive start to life in the Premier League, picking up seven points from their opening three matches, but they suffered their first loss of the campaign when they were beaten 2-0 at West Ham on Monday night.
David Wagner will be hoping his side can bounce back from that loss against Leicester, although they have a poor recent record when they face the Foxes, winning just one of their last nine meetings in all competitions.
Huddersfield will also have to do without Kasey Palmer for the match, after it was confirmed the on-loan Chelsea man faces a number of months on the sidelines with a hamstring injury.
Club-record signing Steve Mounie is also a doubt after picking up a knock against West Ham, although fellow forward Collin Quaner should be fit following a knee injury.
Leicester have only won one of their opening four league matches to date this term, although their losses have come against Arsenal, Manchester United and Chelsea, while their sole success was against newly promoted opposition, as they beat Brighton at the King Power Stadium last month.
The Foxes only secured two league wins on the road last season, against West Ham and West Brom, but they did beat Huddersfield 2-0 on their last visit to the John Smith's Stadium in 2014.
Boss Craig Shakespeare is likely to be without midfielder Matty James for the trip to Yorkshire, as he sustained an Achilles injury against Chelsea last time out, while full-back Christian Fuchs is also a major doubt due to an eye complaint.
Summer signing Kelechi Iheanacho could play a more significant role, after being limited to brief substitute appearances so far this term, while fellow new recruit Vincent Iborra could also feature.