Jurgen Klopp's men go into the clash unbeaten in their last three matches, although they have failed to win any of their last three home games.
It's well documented that the Reds have struggled against teams in the bottom half this term – with defeats to the likes of Burnley, Crystal Palace, Leicester, Hull and Swansea.
Liverpool will hand a late fitness test to Roberto Firmino, who missed the win at West Ham due to a muscle problem. If the Brazilian doesn't make it, then Klopp is expected to start with the same side that won 4-0 at the London Stadium last Sunday.
Meanwhile, Boro go into the match with just one win in their last 20 league games and haven't won away from home since August 21 – with both of those victories coming against bottom-club Sunderland.
Steve Agnew will be without three important players through injury, with Victor Valdes, Gaston Ramirez and Daniel Ayala all sidelined.
Boro have lost on their last four league visits to Anfield, but they did take the Reds to extra-time in last season's League Cup tie – eventually losing on penalties.