Just one point separates the two teams and Saturday's game could prove crucial in the battle for a top-four place come May.
Pep Guardiola will get a good idea of his squad’s mental strength, as he seeks a response to Wednesday night's shock Champions League exit at the hands of French leaders Monaco.
The home side are being tipped to recall both Yaya Toure and Nicolas Otamendi to the starting line up, after both were named on the bench in midweek.
There's still no Gabriel Jesus and Ilkay Gudogan due to injury, while Claudio Bravo is pushing for a recall between the posts.
Meanwhile, Liverpool make the half-an-hour journey to Manchester looking for a third consecutive Premier League win.
The Reds are unbeaten in nine league games this season against the top six teams and they are unbeaten in their last five matches against City.
Liverpool will hand a late fitness test to Roberto Firmino, who missed the win over Burnley due to a knock.
Both Daniel Sturridge and Jordan Henderson will play no part due to injury, while Divock Origi has struggled with illness this week.
Klopp has been boosted though by the news that Dejan Lovren is fit again, after the centre back came through an Under-23 game earlier this week.