The Citizens are unbeaten in their last 19 matches in all competitions and they are currently sitting top of the Premier League standings following a run of five-successive top-flight wins.
Pep Guardiola's side have also netted 22 goals in their seven league games to date, while their last defeat in the division came away at Chelsea in April.
City also boast an impressive record against Stoke, particularly on their own turf, as they have only lost one of their previous 11 home matches against the Potters.
The league leaders could be boosted by the return of leading scorer Sergio Aguero for Saturday's match, as he has recovered from a broken rib quicker than expected.
Midfielder Fabian Delph could also feature, as he has resumed training following a hamstring problem that ruled him out of international duty with England.
Stoke will head into the match on the back of a 2-1 home success over Southampton, a result that brought the Potters run of three straight defeats in all competitions to an end.
Mark Hughes' side secured a 0-0 draw on their last visit to the Etihad Stadium, but they have never kept consecutive away shut outs against the Citizens.
Midfielder Joe Allen will miss the match, after suffering concussion while on international duty with Wales, while defenders Ryan Shawcross and Bruno Martins Indi are unlikely to feature due to respective back and groin complaints.