The Saints have lost back-to-back matches against Manchester United and Stoke, while scoring goals has been a problem for the South Coast club since the tail-end of last season.
Indeed, Southampton have failed to score in eight of their last nine top-flight matches on home soil, with the exception coming in August when they secured a 3-2 success against 10-man West Ham.
Southampton do have an impressive home record against Newcastle, however, as they have lost just one of their 16 Premier League meetings with the Magpies on home soil.
Boss Mauricio Pellegrino has a no new injury concerns heading into the match, as forward Shane Long appears to have recovered from the hip injury that forced him to miss Republic of Ireland's victory over Wales during the week.
Newcastle have proved a difficult team to beat following their return to the Premier League, as they have only lost one of their last five top-flight matches, although that defeat did come on the South Coast against Brighton.
In fact the Magpies have only won one of their last 14 away matches in the top-flight, with their last victory at St Mary's coming way back in September 2004.
Rafael Benitez should be able to call upon Jonjo Shelvey for the match, even though the midfielder is nursing a broken finger, while Matt Ritchie and Christian Atsu are also expected to be available following minor fitness issues.