Spurs' recent strong results have lifted them into fifth in the Premier League table and Mauricio Pochettino's men are looking to climb into the top four this weekend.
Tottenham have won four of their last five matches and confidence is high after Pochettino was able to rest several of his first-team squad for the FA Cup third round win over Wimbledon.
Pochettino will be without midfielder Harry Winks as he continues to struggle with an ankle injury, while defenders Danny Rose and Toby Alderweireld remain unavailable.
Everton boss Sam Allardyce will be able to call upon new signing Cenk Tosun after he completed his £27million move from Besiktas. He has trained all week but may have to settle for a place on the bench this weekend.
Allardyce will be without defender Michael Keane due to a gashed foot, while midfielder Idrissa Gueye is on the sidelines with a hamstring complaint.
The Toffees are looking for their first win in five matches but they will have to break Spurs' recent record to do so.
Tottenham are unbeaten in the last 10 league meetings between the two sides and they have 24 wins over them in the Premier League, more than against any other side.