The Baggies remain 19th in the league table and boss Alan Pardew is still waiting for his first win in charge in the league but he did get some joy in the FA Cup last weekend.
West Brom travelled to Exeter and recorded a 2-0 win but the former Crystal Palace manager needs to get his team going in the Premier League.
He faces a number of selection headaches with Jonny Evans, Kieran Gibbs and Matt Phillips all struggling with injuries.
Midfield duo James Morrison and Nacer Chadli both remain on the sidelines but Brighton coach Chris Hughton is also pondering changes due to injuries.
Winger Izzy Brown suffered a season-ending knee injury against Crystal Palace on Monday, while Steve Sidwell has suffered a setback in training.
West Brom have a strong record against Brighton at The Hawthorns, having not lost on their own patch in their last nine meetings.
Karen Brady 'Let me be frank. The Board takes full responsibility for our predicament'
Despite being three wins away from FA Cup glory, Mauricio Pochettino has admitted the achievement would pale in comparison to a Premier League title.
Under-fire Baggies coach Alan Pardew has demanded his senior players improve their performance and help the troubled bottom of the table English Premier League side get a win in Saturday's fixture against Bournemouth.
Liverpool will want to banish the recent memory of losing to fierce rivals Manchester United with a big win against Watford at Anfield on Saturday evening.
Struggling Stoke City manager Paul Lambert is determined to keep his side in the Premier League ahead of Saturday's crucial clash against Everton at the Bet365 Stadium in Staffordshire.