The Foxes booked their place in the last eight of Europe’s premier club competition with a 3-2 aggregate success over Sevilla during the week, and they will now face Atletico Madrid in the quarter-finals.
West Ham by contrast have had a full week to prepare for the match, but they head into the contest following back-to-back league defeats to Chelsea and Bournemouth.
Indeed the Hammers have only won on of their last five league matches on home soil and boss Slaven Bilic is expecting another tough test against a Leicester side that have been rejuvenated under the stewardship of Craig Shakespeare.
Bilic has been dealt a blow ahead of the fixture as captain Mark Noble has been ruled out with a dead leg.
Winston Reid is expected to deputise as skipper in Noble’s absence, while Sam Byram and Andre Ayew could both return to the starting line-up after coming on as substitutes against Bournemouth.
Leicester will head into the contest having won their last three matches since Shakespeare succeeded Claudio Ranieri as manager, including victories against Hull and Liverpool in the league.
Those results have lifted the Foxes three points clear of the relegation zone, although they have not won three successive top-flight games since last season’s title run in.
The Foxes are likely to be without midfielder Nampalys Mendy once again on Saturday, as he continues to struggle with a knee injury.
Danny Drinkwater is available for selection however, despite ruling himself out of England duty due to an ongoing injury complaint.
Leicester are unbeaten in the last five league and cup meetings between the two sides, with West Ham’s last success in the fixture coming at Upton Park in December 2014.