The Red Devils scored their first four kicks through Ryan Giggs, Carlos Tevez, Cristiano Ronaldo and Anderson to capitalise after Jamie O’Hara was denied by Ben Foster and David Bentley fired wide.
United could have won the game inside the 90 minutes but Ronaldo’s injury-time drive came back off the inside of the post, while the Portugal international was harshly booked for diving in the 67th minute when he should have won a penalty following a Ledley King challenge.
Patrice Evra shot over just before the end of extra-time while Spurs’ best chances fell to Aaron Lennon and Darren Bent.
On 71 minutes Foster was forced to beat away a vicious drive from Lennon before denying bent with his legs from 10 yards with 126 minutes on the clock.
But Sir Alex Ferguson’s men kept their nerve in the shoot-out – as they did in the Champions League final against Chelsea last May – to lift the first domestic honour of the campaign and stay in the hunt for a clean sweep.
Bayern Munich CEO Karl-Heinz Rummenigge has again insisted Robert Lewandowski will not be leaving the club this summer.
Diego Simeone is ignoring rumours linking Antoine Griezmann with a move from Atletico Madrid and is focused on the last two games.
Real Madrid forward Lucas Vazquez could be on his way to Liverpool at the end of the season, according to reports in Spain.
Everton look set to be disappointed with their attempts to lure Jack Wilshere as the player is poised to stay with Arsenal.
Newcastle boss Rafael Benitez was pleased with the performance of his players as they slipped to a 1-0 defeat at Tottenham.
Bournemouth striker Jermain Defoe is still hoping experience counts for a lot and he will make England's World Cup squad.
Arsene Wenger has told Jack Wilshere he should stay at Arsenal and believes the player is close to agreeing a new deal.
Mauricio Pochettino was bursting with pride after seeing Tottenham book a third successive season in the Champions League.