The Red Devils scored their first four kicks through Ryan Giggs, Carlos Tevez, Cristiano Ronaldo and Anderson to capitalise after Jamie O'Hara was denied by Ben Foster and David Bentley fired wide.
United could have won the game inside the 90 minutes but Ronaldo's injury-time drive came back off the inside of the post, while the Portugal international was harshly booked for diving in the 67th minute when he should have won a penalty following a Ledley King challenge.
Patrice Evra shot over just before the end of extra-time while Spurs' best chances fell to Aaron Lennon and Darren Bent.
On 71 minutes Foster was forced to beat away a vicious drive from Lennon before denying bent with his legs from 10 yards with 126 minutes on the clock.
But Sir Alex Ferguson's men kept their nerve in the shoot-out - as they did in the Champions League final against Chelsea last May - to lift the first domestic honour of the campaign and stay in the hunt for a clean sweep.
Match Reports last week