Boro have won both their previous two visits to the Bluebirds' new home while the Red Dragons have won all eight games on their own patch so far this season.
But newly-named Manager of the Month for October Tony Mowbray insists his side are going to south Wales in an upbeat mood as he comes up against old team-mate Malky Mackay.
"We've been there for the last two seasons and won but Cardiff have won all eight home games, so it's going to be very tough," he told the club's official website.
"At this moment Cardiff are up there with anyone else if you're going to pick a favourite to get out of this league. They've got a strong squad and some very talented individual players.
"But we've just come off the back of a really tough run of games but we've got a good team spirit, belief and a desire not to lose - so let's see if we can get another away victory."