Alex Bruce limped off with a recurrence of a groin problem against Brentford and Curtis Davies (calf) remains sidelined, leaving Maguire to partner Michael Dawson.
Manager Steve Bruce will be hoping to coax another start out of tiring striker Abel Hernandez.
With Sone Aluko and Adama Diomande still out, he has had a heavy workload in recent weeks but the visit of Middlesbrough may not be the time to rest the eight-goal top-scorer.
Middlesbrough boss Aitor Karanka will not risk striker Cristhian Stuani for the top-of-the-table Championship clash.
Stuani has missed Boro's last six games since returning from international duty with Uruguay with hamstring and groin injuries.
And Karanka has expressed concern that Stuani is set to jet-off again this week for next Thursday's World Cup qualifier against Ecuador.
Meanwhile, Karanka will also be without David Nugent who has shrugged off a hamstring strain but the striker will be given an extra fortnight to recuperate.