The Magpies welcome Jose Mourinho's men to St James' Park on Saturday still smarting from both their 2-1 derby defeat at Sunderland and Wednesday night's extra-time exit from the Capital One Cup at the hands of Manchester City.
Now Pardew has challenged his team to launch a fightback by slaying one of the Premier League's biggest powers.
He said on Thursday: "It can transform your season, a win against Chelsea or Spurs, and that's what we have got to look for.
"It is frustrating because it's difficult when there's such emotion riding after the Sunderland game, and I understand that.
"But we are hurt as well. When you have played your heart out and in the 85th minute the opposition smash it in the top corner...
"We are down and we need a lift and I hope our fans give us a lift on Saturday. They did last night and we responded to that, and they need to be in really, really good voice for us to have a chance against Chelsea."