Wanderers can clinch promotion to the Premier League if they beat their near-neighbours this weekend, although they may have already sealed their place in the top-flight before kick-off, depending if results go their way on Saturday.
Either way, Santo is expecting a tough test against a Birmingham side that are fighting against relegation and have improved since Garry Monk's arrival as manager last month.
'The game is not going to be a party. We know the importance of the game and what it means to us,' Nuno said. 'When you are talking about the derby everything changes. What I really expect is a good atmosphere.
'It's going to be very difficult. They changed managers and I think Garry is doing a very good job. The results are there and they are fighting for their lives.'
Nuno feels the match should certainly be an entertaining one, as both teams are desperate for the points for very different reasons.
He added: 'We are fighting for something really important for us - to win at Molineux in front of our crowd. All the ingredients for a good game are there.'
Steven Gerrard admitted he has concerns about Rangers' shot-shy strike-force after their stalemate with FK Shkupi in Macedonia.
Sunderland midfielder Wahbi Khazri has completed his move to French club St-Etienne, the Black Cats have announced.