Both players were included on the bench against Preston on Saturday following injury and came on as late substitutes towards the end of the 1-1 draw at Deepdale.
Saiss, along with Ruben Neves, is just one yellow card away from a two-game suspension for accumulating 10 cautions.
Phil Ofosu-Ayeh (ankle) is still a long-term absentee for the runaway Championship leaders.
Fit-again captain Ivo Pinto looks likely to return to the Norwich starting line-up.
The defender has recovered from a knee problem he sustained when getting out of his car and was an unused substitute for the derby draw with Ipswich on Sunday.
New boys Onel Hernandez and Dennis Srbeny are also pushing for their first starts while on-loan Tottenham midfielder Marcus Edwards (back) may also be in contention for a belated debut.
Matt Jarvis has returned to training after a long-term ankle problem but it is probably too soon for the winger to be considered.
Newcastle have been linked with a shock move for former Sunderland goalkeeper Simon Mignolet during the summer.