The under-fire Cottagers chief has been without the Belgium international hitman for five weeks due to an ankle injury. And, despite hoping that Dembele would be back for the Boxing Day clash against West Ham, he failed a fitness test and missed the damaging 3-1 defeat, which left the side in the relegation places.
Hughes is now unlikely to have Dembele available for the trip to the Britannia Stadium as he looks for his side to secure a win to ensure he stays in the job at Craven Cottage.
It will be hoped that Dembele can return for the visit of Tottenham on Saturday, but Matthew Briggs remains out until next month with a calf injury, while Bobby Zamora and Philippe Senderos should return in February from broken leg and Achilles injuries respectively.
Rangers centre-back Russell Martin will miss Scotland's friendlies against Costa Rica and Hungary through injury.
Jonathan Walters is ready to continue his Republic of Ireland career when he returns to full fitness, according to Martin O'Neill.