The Canaries were flying high after their first win in 10 Barclays Premier League games against Everton last week but came crashing down to earth at Old Trafford as they were hit by Shinji's Kagawa's hat-trick.
It leaves Norwich still eight points clear of the drop zone, but with a grim goal difference that would count against them if they ended up getting sucked into a scrap for survival.
To avoid that, Norwich need to post another couple of wins.
And with their next three games against Southampton, Sunderland and Wigan, Hughton never felt the outcome at Old Trafford was going to prove pivotal.
"That game was never going to define our season," said Hughton.
"Only one team has won at Old Trafford."
Instead, Hughton is wanting to experience a few more home comforts, knowing Swansea, Reading, Aston Villa and West Brom also have to visit Carrow Road before the campaign reaches its conclusion.
"Home games are key," he said. "It is the same for most clubs at our level. The bonuses are what you can get away.
"We will bounce back. This result hurts me because it is not a fair reflection of how we played. But we have a very big game at home to Southampton now, so we will dust ourselves down and look forward."