Calzaghe is one of just two men to beat Kessler but the Welshman thinks Froch will add to the Danish star's career defeats when they meet at the end of May.
"Fighting at home is a massive advantage for Froch as well. He is improving with age and in his last couple of fights he has looked impressive," Calzaghe told the Express.
"But Kessler will be a different kettle of fish.
"It will be a great fight. Kessler is still a warrior and he still has a big punch. You can never write him off. But if I have to vote for one of them, I'd have to go with Froch."
Froch suffered a first ever career defeat against Kessler in their first meeting in 2010, with the Dane securing a points decision in his home country.
Calzaghe turned down a number of chances to fight Froch towards the end of his career but insists he has no regrets over his decision and claims there is no animosity between himself and the 35-year-old.
"Listen, I don't have any regrets about not fighting Froch because back in the day when I was fighting, he was a nobody," said Calzaghe on turning down Froch.
"If Carl Froch, four years ago, was like he is today, then of course I would have fought him, it would have been a massive occasion.
"But it's a similar parallel now between Froch and, say, George Groves.
"I was fighting the best fighters in the world and in America, so taking on Froch would have been a big step down."
He added: "There's no animosity between us now.
"He believes that he's the best fighter, whereas I believe, 100 per cent, that I would have won a fight between us in great style."