The 39-year-old seven-time Tour de France winner has decided to hang up his riding shoes for good after an entertaining career.
He said: "I can't say I have any regrets. It's been an excellent ride."
The Texan retired from cycling back in 2005 only to return for the 2009 Tour, but now it appears his competitive career is finally over.
Armstrong is currently facing a US federal investigations into doping allegations made by former team-mate Floyd Landis, who claimed Armstrong had used banned drugs.
Regarding the doping claims and investigation, Armstrong said: "I can't control what goes on in regards to the investigation.
"That's why I hire people to help me with that. I try not to let it bother me and just keep rolling right along. I know what I know.
"I know what I do and I know what I did. That's not going to change."