The 39-year-old seven-time Tour de France winner has decided to hang up his riding shoes for good after an entertaining career.
He said: “I can’t say I have any regrets. It’s been an excellent ride.”
The Texan retired from cycling back in 2005 only to return for the 2009 Tour, but now it appears his competitive career is finally over.
Armstrong is currently facing a US federal investigations into doping allegations made by former team-mate Floyd Landis, who claimed Armstrong had used banned drugs.
Regarding the doping claims and investigation, Armstrong said: “I can’t control what goes on in regards to the investigation.
“That’s why I hire people to help me with that. I try not to let it bother me and just keep rolling right along. I know what I know.
“I know what I do and I know what I did. That’s not going to change.”
Sunderland have vowed to 'rise again' after their relegation to League One was confirmed on Saturday afternoon.
Diego Simeone has admitted he expects Diego Costa to miss the first leg of Atletico Madrid's Europa League semifinal against Arsenal.
Brentford moved to within a point of the Championship play offs with a pulsating 2-1 win over west London derby rivals QPR.
Aston Villa kept their automatic promotion bid alive with a convincing 4-0 victory over 10-man Ipswich at Portman Road.
Middlesbrough further enhanced their quest for a Championship play-off place with a convincing win at fellow hopefuls Derby.