Wilshere, 21, returned from more than a year out injured in October but is already being heralded as an integral part of England’s future following his man-of-the-match display in the 2-1 win over Brazil at Wembley on Wednesday night.
Wenger knows the progress of the combative midfielder must be carefully handled if both Arsenal and England are to see the best of the player over the long term.
“It is not just the physical aspect, but the mental pressure every time he plays. We will have to manage him well physically to make sure he doesn’t face that burnout,” said Wenger, whose side resume Barclays Premier League action at Sunderland on Saturday.
“I had in fact expected Jack to play only a part of the game on Wednesday, but it didn’t happen and because of his quality he will be exposed to that, the overuse of his quality, and you can understand that.
“He will have to be managed like everyone else.
“Let’s not forget that he is only 21 now, and he starts his career really because he was out for 17 months.
“The influence he has today on the England national team already is absolutely fantastic.”
Chesterfield boss Jack Lester felt his side were unlucky not to claim all three points after their 1-1 draw at Cheltenham.
New Swindon manager Phil Brown revelled in his side's victory at Cambridge in his first game in charge.
Graham Westley believed his side 'disintegrated' in the second half of their 2-0 loss against Wycombe.
Port Vale manager Neil Aspin praised his side's 'fighting spirit' after they came back from two goals down to draw 2-2 with Stevenage at Vale Park.
Garry Monk had every reason to have a wide smile on his face after guiding Birmingham to a vital 3-0 Championship home win over below-par Hull.
Lee Johnson was delighted for Milan Djuric after the striker's 64th minute goal boosted Bristol City's Sky Bet Championship play-off bid.
Sheffield United manager Chris Wilder was left frustrated with his team's quality in the final third after they drew 0-0 against Nottingham Forest.
Mark Robins praised his players resilience as Coventry's game management counted in a hard-fought victory at Crewe.