The 23-year-old has spent the last three seasons on loan at Wolves but has often stated he would like to try to force his way into the Blues first team at some point in the future.
Having not been given the opportunity to showcase his talents in the first eleven Mancienne looks set to take the opportunity to move on, with Hamburg looking for a new centre half after a poor season defensively.
The former England under-21 international is reportedly ready to fly in to Hamburg on Tuesday for a medical and will pen a four-year contract if all goes well.
Mancienna is expected to be the first of a number of Chelsea youngsters who will leave the club this summer after failing to make the grade at Stamford Bridge.
A goal apiece from James Tomkins and Luka Milivojevic handed Crystal Palace a crucial 2-0 win over Huddersfield at the John Smith's Stadium on Saturday evening.
Manchester United bounced back from their Champions League exit as they beat Brighton 2-0 at Old Trafford on Saturday night to reach the FA Cup semi-finals.
Tottenham reached the FA Cup semi-finals after they cruised to a 3-0 victory over Swansea in their quarter-final clash at the Liberty Stadium on Saturday.
Premier League basement club West Brom squandered the lead as they suffered a 2-1 defeat to Bournemouth at the Vitality Stadium on Saturday.
Chesterfield boss Jack Lester felt his side were unlucky not to claim all three points after their 1-1 draw at Cheltenham.
New Swindon manager Phil Brown revelled in his side's victory at Cambridge in his first game in charge.