Wickham sustained an anterior cruciate ligament knee injury in Palace’s defeat at Swansea on Saturday and now requires an operation.
The club have so far refused to put a timescale on the 23-year-old’s return but he seems set to miss the remainder of the current campaign.
The striker has since taken to Twitter to reveal his disappointment, and has vowed to return “stronger than before”.
He tweeted: “I can’t describe how devastated I am, but I will do all I can to be back on the pitch as soon as possible and stronger than before!”
Former Swansea caretaker boss Alan Curtis believes Carlos Carvalhal deserves great credit for the impact he has had at the club.
West Ham have issued life bans to five pitch invaders who came onto the playing surface in the defeat to Burnley last time out.
Brighton centre-half Shane Duffy says his game has come on leaps and bounds thanks to Chris Hughton and Martin O'Neill.
Bournemouth midfielder Lewis Cook says he is ready to take his chance with England should he be handed his senior debut.
Tottenham will have to make a massive offer to land Wilfried Zaha, according to former Crystal Palace chairman Simon Jordan.
Nigel Clough believes keeping Burton in the Championship this season will surpass the achievements of last term's survival.
Garry Monk has challenged his Birmingham players to maintain the high standards they set when beating Hull in their last league game.
Former manager Mark Warburton claims Rangers need to be patient with Graeme Murty or suffer the 'same old problems'.