The influential Belgium international, who has been exceptional this season, sits out the visit of Norwich due to suspension for picking up too many bookings.
His absence could be offset by the return of former Manchester United man Gibson, who has been out with a thigh injury since the clash with West Brom back at the beginning of September.
Belgium international Mirallas pulled a hamstring against Sunderland and missed the clash with Reading but may be fit to play Norwich depending on a late test.
Tony Hibbert also faces a late check but may have to settle for a place on the bench and skipper Phil Neville is out following recent surgery.
Pedro stepped off the bench to send Chelsea into the FA Cup semi-finals after they beat Leicester 2-1 at the King Power Stadium on Sunday evening.
RB Leipzig came from behind at the Red Bull Arena to end a run of four winless games and defeat Bundesliga leaders Bayern Munich 2-1 on Sunday.