The Russian was sent off against West Brom last weekend but Everton had hoped his appeal would be successful, especially after Baggies midfielder James Morrison gave him a statement of support, but it has still failed meaning he will miss the final-day clash with Chelsea and the opening two games of next season.
A club statement said: “Everton were informed on Tuesday afternoon that referee Anthony Taylor’s decision would be upheld, thus ruling Bilyaletdinov out of Sunday’s Premier League finale against Chelsea, as well as the first two games of next season.
“The appeal was dismissed in spite of Morrison providing a statement in support of the Everton player.”
A goal apiece from James Tomkins and Luka Milivojevic handed Crystal Palace a crucial 2-0 win over Huddersfield at the John Smith's Stadium on Saturday evening.
Manchester United bounced back from their Champions League exit as they beat Brighton 2-0 at Old Trafford on Saturday night to reach the FA Cup semi-finals.
Tottenham reached the FA Cup semi-finals after they cruised to a 3-0 victory over Swansea in their quarter-final clash at the Liberty Stadium on Saturday.
Premier League basement club West Brom squandered the lead as they suffered a 2-1 defeat to Bournemouth at the Vitality Stadium on Saturday.