Goalkeeper Joel Robles is expected to feature in goal after starting the 1-0 win over Watford last weekend.
Dutchman Maarten Stekelenburg is still nursing a groin injury and he now joins the club’s long list of absentees.
Aaron Lennon, James McCarthy, Seamus Coleman, Ramiro-Funes Mori and Yannick Bolasie are still out but Koeman has no new injury worries for the final game of the campaign.
Provisional squad: Robles, Holgate, A Williams, Jagielka, Baines, Gueye, Schneiderlin, Davies, Barkley, Mirallas, Lukaku, Hewelt, Pennington, Barry, Besic, J Williams, Valencia, Kone.
Sheffield United could have leading scorer Leon Clarke back for their home game against Nottingham Forest.