The Toffees have a growing injury list to contend with but Koeman believes he has plenty of strength in depth to deal with the issues.
Ross Barkley, Seamus Coleman, Yannick Bolasie, Ramiro Funes Mori and James McCarthy have all remained at home due to injuries.
However, with nine new arrivals over the summer, Koeman is certainly not short on options as they look to start positively in Europe.
Nikola Vlasic could be handed a full debut following his switch from Hajduk Split, while youngster Ademola Lookman is also pushing for a first start of the campaign.
Pedro stepped off the bench to send Chelsea into the FA Cup semi-finals after they beat Leicester 2-1 at the King Power Stadium on Sunday evening.
RB Leipzig came from behind at the Red Bull Arena to end a run of four winless games and defeat Bundesliga leaders Bayern Munich 2-1 on Sunday.